Precol Long-Acting Capsules 36 Capsules [Designated Class 2 OTC Drug]

Product Information

Combination cold medicine <Pyrine-type> Contains isopropylantipyrine

1. A long-acting cold medicine whose excellent effect continues with 2 doses a day.
2. By combining granules that dissolve and work immediately after taking (fast-dissolving granules) with granules that dissolve and work later (slow-dissolving granules), the effect lasts with 2 doses a day: take it in the morning and it lasts until night, take it at night and it lasts until morning.
3. 7 active ingredients, including the 2 antipyretic analgesic ingredients IPA (isopropylantipyrine) and acetaminophen, work well on the troublesome symptoms of a cold, such as sore throat and fever.

Deviating from the specified dosage and administration of a medicine can lead to serious harm to health. Always read the product instructions carefully before use and follow the dosage and administration. Even when a medicine is used correctly according to the dosage and administration, side effects may occur. If you notice anything unusual, stop use immediately and consult a doctor or pharmacist.

About the Sale of Medicines

●Precautions for Use
■■Things You Must Not Do■■ (If not observed, current symptoms may worsen or side effects/accidents may become more likely to occur)
1. The following persons must not take this medicine.
(1) Persons who have had allergic symptoms caused by this medicine or its ingredients
(2) Persons who have had asthma caused by taking this medicine or other cold medicines or antipyretic analgesics
(3) Children under 15 years
2. While taking this medicine, do not use any of the following medicines.
Other cold medicines, antipyretic analgesics, sedatives, antitussive and expectorants, oral medicines containing antihistamines, etc. (oral medicines for rhinitis, motion sickness medicines, allergy medicines, etc.)
3. Do not drive a vehicle or operate machinery after taking this medicine.
(Drowsiness, etc. may occur)
4. Persons who are breastfeeding should not take this medicine, or if taking this medicine, should avoid breastfeeding.
5. Do not drink alcohol before or after taking this medicine.
6. Do not use continuously for a long period.
■■Things To Consult On■■
1. The following persons should consult a doctor, pharmacist, or registered salesclerk before taking this medicine.
(1) Persons receiving treatment from a doctor or dentist
(2) Persons who are pregnant or who think they may be pregnant
(3) Elderly persons
(4) Persons who have had allergic symptoms caused by medicines, etc.
(5) Persons with the following symptoms: high fever, difficulty urinating
(6) Persons who have received the following diagnoses: thyroid dysfunction, diabetes, heart disease, high blood pressure, liver disease, kidney disease, gastric/duodenal ulcer, glaucoma, respiratory dysfunction, obstructive sleep apnea syndrome, obesity
2. If any of the following symptoms appear after taking this medicine, they may be side effects. Stop taking it immediately and consult a doctor, pharmacist, or registered salesclerk, bringing this document with you.

Relevant Area – Symptoms
Skin – Rash/redness, itching, swelling
Digestive system – Nausea/vomiting, loss of appetite, upper abdominal pain, heartburn
Psychiatric/nervous system – Dizziness
Urinary system – Difficulty urinating
Other – Excessive drop in body temperature

The following serious symptoms may occur rarely.
In such cases, see a doctor immediately.

Symptom Name – Symptoms
Shock (anaphylaxis) – Immediately after taking the medicine, itching of the skin, hives, hoarseness, sneezing, itching of the throat, difficulty breathing, palpitations, clouding of consciousness, etc. appear.

Oculomucocutaneous syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis, acute generalized exanthematous pustulosis – High fever, red eyes, eye discharge, sores on the lips, sore throat, widespread rash/redness of the skin, small bumps (small pustules) appearing on reddened skin, general fatigue, loss of appetite, etc. persist or rapidly worsen.

Drug-induced hypersensitivity syndrome – Redness over a wide area of the skin, generalized rash, fever, physical fatigue, swelling of lymph nodes (neck, armpits, groin, etc.), etc. appear.

Liver dysfunction – Fever, itching, rash, jaundice (yellowing of the skin or the whites of the eyes), brown urine, general fatigue, loss of appetite, etc. appear.

Kidney damage – Fever, rash, decreased urine output, swelling of the whole body, general fatigue, joint pain (aching joints), diarrhea, etc. appear.

Interstitial pneumonia – Shortness of breath or difficulty breathing when climbing stairs or exerting yourself slightly, dry cough, fever, etc. appear suddenly or persist.

Asthma – Wheezing or whistling sounds when breathing, difficulty breathing, etc. appear.

Aplastic anemia – Bruises, nosebleeds, bleeding from the gums, fever, pale-looking skin and mucous membranes, fatigue, palpitations, shortness of breath, feeling unwell and light-headed, blood in the urine, etc. appear.

Agranulocytosis – Sudden high fever, chills, sore throat, etc. appear.

Respiratory depression – Shortness of breath, difficulty breathing, etc. appear.

3. The following symptoms may appear after taking this medicine. If they persist or worsen, stop taking it and consult a doctor, pharmacist, or registered salesclerk, bringing this document with you.
Constipation, dry mouth, drowsiness

4. If symptoms do not improve after taking 5 to 6 doses, stop taking it and consult a doctor, pharmacist, or registered salesclerk, bringing this document with you.



●Indications
Relief of cold symptoms (sore throat, fever, runny nose, nasal congestion, cough, phlegm, chills, headache, joint pain, muscle pain, sneezing)



●Dosage and Administration
Take the following dose with water or hot water.
Age – Single dose – Times per day
Adults (15 years and older) – 2 capsules – 2 times (after breakfast and dinner, within 30 minutes if possible)
Under 15 years – Do not take.

<Precautions related to dosage and administration>
(1) Strictly follow the dosage and administration.
(2) How to remove the capsules: Press the raised part of the PTP sheet containing the capsule firmly with your fingertip to break the aluminum foil on the back, take out the capsule, and then take it. (Accidentally swallowing the capsule still in the sheet may lead to unexpected accidents, such as the sheet piercing the mucous membrane of the esophagus)



●Ingredients and Amounts
This medicine consists of yellow and white capsules, and 4 capsules contain the following ingredients.
Ingredient – Amount – Action
Isopropylantipyrine (pyrine-type) – 300 mg
– Lowers fever and relieves sore throat, headache, and joint pain.

Acetaminophen – 450 mg
– Lowers fever and relieves sore throat, headache, and joint pain.

Chlorpheniramine maleate – 7.5 mg
– Suppresses runny nose, nasal congestion, and sneezing.

Dihydrocodeine phosphate – 12 mg
– Calms coughing.

dl-Methylephedrine hydrochloride – 60 mg
– Calms coughing and suppresses phlegm.

Glycyrrhiza extract powder – 118 mg (equivalent to 983 mg of crude drug)
– Calms inflammation of the mucous membranes of the throat and nose.

Anhydrous caffeine – 75 mg
– Relieves headache.

Additives: lactose, hydroxypropylcellulose, corn starch, silicon dioxide, methacrylic acid copolymer L, stearic acid, talc, cellulose, carmellose calcium, gelatin, sodium lauryl sulfate



●Precautions for Storage and Handling
(1) Store in a cool place with low humidity, away from direct sunlight.
(2) Store out of the reach of children.
(3) Do not transfer to another container. (This may cause misuse or change the quality)
(4) Do not use the product after the expiration date shown.



●Contact Information
For inquiries about this product, please contact the store where you purchased it or the following.
Daiichi Sankyo Healthcare Co., Ltd. Customer Consultation Office
〒103-8234 東京都中央区日本橋3-14-10
Tel. 0120-337-336
Hours: 9:00 to 17:00 (excluding Saturdays, Sundays, and public holidays)

Manufacturer and Distributor
Daiichi Sankyo Healthcare Co., Ltd.
東京都中央区日本橋3-14-10